Solid-State Chemistry of Copper-Based Coordination Polymers: Enhanced Stability and Biological Activity
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Abstract
Copper-based coordination polymers have emerged as promising materials combining structural versatility with significant biological applications, particularly in enzyme inhibition. This comprehensive study investigates the solid-state chemistry of copper coordination polymers, focusing on their enhanced stability and biological activity against urease enzymes. The research explores synthetic methodologies, structural characterization, and the relationship between molecular architecture and biological efficacy. Various copper complexes incorporating pyridine-based ligands and auxiliary molecular frameworks demonstrate remarkable urease inhibitory properties, with some compounds achieving inhibition efficiencies exceeding 85% under physiological conditions. The investigation reveals that coordination geometry, ligand selection, and solid-state packing significantly influence both thermal stability and biological activity. Thermogravimetric analysis indicates decomposition temperatures ranging from 280°C to 350°C, while X-ray crystallographic studies confirm diverse coordination environments including square planar, tetrahedral, and octahedral geometries. The biological evaluation demonstrates that copper-containing coordination polymers exhibit superior urease inhibition compared to traditional organic inhibitors, with IC₅₀ values in the micromolar range. These findings contribute to understanding structure-activity relationships in copper-based materials and provide insights for designing next-generation therapeutic agents targeting urease-related pathologies.
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