Journal of Science, Innovation & Social Impact
type: channel
description: Journal of Science, Innovation & Social Impact (JSISI) is an international, refereed, double-blind peer-reviewed, open-access journal dedicated to publishing high-quality research at the interface of scientific discovery, technological innovation, and societal impact. The journal welcomes interdisciplinary studies that advance both theoretical knowledge and practical applications, with a focus on topics such as emerging scientific breakthroughs, innovation-driven solutions, societal challenges, policy implications, and the broader social consequences of scientific and technological advancements.
language: en
publication name: Journal of Science, Innovation & Social Impact
issn: 3105-501X
items: Enhanced Feature Engineering and Algorithm Optimization for Real-Time Detection of Synthetic Identity Fraud and Money Laundering in Financial Transactions
items: Machine Learning-Based Credit Risk Early Warning System for Small and Medium-Sized Financial Institutions: An Ensemble Learning Approach with Interpretable Risk Indicators
items: Research on Mobile Advertising Click-Through Rate Prediction Algorithm Based on Differential Privacy
items: Research on Intelligent Firmware Vulnerability Detection and Priority Assessment Method Based on Hybrid Analysis
items: Multi-Source Data Fusion for Short-Term Demand Forecasting of Seasonal Retail Products: An Empirical Study Using Weather and Social Media Signals
items: FTAFO: A Federated Transparent Adaptive Financial Optimizer for Reducing Third-Party Dependencies in Workflow Management
items: Enhanced Multi-Modal Feature Fusion Algorithm for Early-Stage Cancer Detection: A Comparative Study of Optimization Strategies
items: Deep Reinforcement Learning-Driven Efficacy-Toxicity Balance Optimization Strategy for Personalized Drug Combination in Cancer Patients
items: Graph Attention-Based Feature Selection for Multi-Omics Drug Target Prediction in Cardiovascular Diseases
items: Adaptive Privacy-Preserving Techniques for Multimedia Content Processing in Cloud Environments: A Differential Privacy Approach
items: Efficiency Comparison of Automated Tools versus Traditional Methods in Anti-Money Laundering Compliance Auditing for Banking Institutions
items: Data-Driven Analysis of Transportation Route Efficiency and Carbon Emission Correlation in Retail Distribution Networks
items: AI-Enhanced Cybersecurity for Financial Networks: A Federated Learning Implementation
items: Medical Terminology Definition-Enhanced Retrieval-Augmented Generation for Hallucination Mitigation in Medical Question Answering
items: Cultural-Intelligent Dynamic Medical Animation Generation for Cross-Lingual Telemedicine Communication Enhancement
items: AI-driven Sustainable Urban Intelligence: Integrating Smart Technologies for Efficient, Resilient, and Inclusive City Management
items: Machine Learning and Cloud-Enhanced Real-Time Distributed Systems for Intelligent Urban Services
items: Fabrication of Copper(II) Coordination Complexes Modulated by Flexible Dicarboxylate Ligands with Notable Urease Inhibitory Performance
items: Efficiency and Productivity Enhancement in Modern Professional Practice: Strategies, Challenges, and Best Practices
items: Design and Synthesis of Novel Copper-Based Coordination Polymers with Enhanced Urease Inhibition Activity
items: Coordination Polymer Design for Catalytic Efficiency Enhancement
items: Auxiliary Ligand Effects on Metal Coordination Polymer Properties
items: Technology-Driven Efficiency Improvements in Modern Professional Fields
items: Performance Optimization Strategies Across Contemporary Industry Practices
items: Digital Transformation and Innovation Across Interdisciplinary Professional Sectors
items: Bimetallic Systems for Tandem Catalytic Reaction Pathways
items: Metal-Organic Framework Stability in Environmental Conditions for Agriculture: Durability and Performance Analysis
items: Multifunctional Copper-Based Coordination Polymers for Biotechnological Applications: Integration and Performance Evaluation
items: Ligand Architecture Impact on Coordination Polymer Biological Activity: Structure-Function Relationship Studies
items: Inorganic Communication Networks through Two-Dimensional Coordination Polymers: Environmental and Biological Applications

Enhanced Feature Engineering and Algorithm Optimization for Real-Time Detection of Synthetic Identity Fraud and Money Laundering in Financial Transactions
type: item
description: The proliferation of digital financial transactions has created unprecedented opportunities for sophisticated fraud schemes, particularly synthetic identity fraud and money laundering activities that evade traditional rule-based detection mechanisms. This research introduces an enhanced feature engineering framework coupled with optimized machine learning algorithms to address the dual challenges of improving detection accuracy while minimizing false positive rates. The proposed methodology integrates temporal, behavioral, and network-based features specifically designed to capture the subtle patterns characteristic of synthetic identity fraud and money laundering transactions. Seven (including stacking ensemble) machine learning algorithms were systematically evaluated using real-world financial transaction datasets, with comprehensive performance analysis conducted through stratified cross-validation. Experimental results demonstrate that XGBoost achieved an F1-score of 0.938 and a Precision of 0.947, delivering the best balance between accuracy and real-time performance.
subject: Articles
  topic: section
subject: financial fraud detection
  topic: keywords
subject: feature engineering
  topic: keywords
subject: synthetic identity fraud
  topic: keywords
subject: money laundering detection
  topic: keywords
creator: Yutong Huang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-30
publication date: 2025-11-30
starting page: 384
ending page: 397

Machine Learning-Based Credit Risk Early Warning System for Small and Medium-Sized Financial Institutions: An Ensemble Learning Approach with Interpretable Risk Indicators
type: item
description: Small and medium-sized financial institutions encounter distinct challenges in implementing effective credit risk management systems due to limited resources and technological infrastructure. This study develops an ensemble learning framework tailored for early warning detection in credit portfolios, addressing the urgent need for cost-efficient risk assessment solutions. The proposed methodology combines multiple machine learning algorithms through a hierarchical voting mechanism, effectively handling imbalanced financial datasets with specialized resampling techniques. Experimental validation using real-world credit data from regional banks demonstrates strong performance, achieving 87.3% accuracy in default prediction over a 12-month forecast horizon. The framework also incorporates interpretable feature importance analysis, enabling risk managers to identify key indicators of portfolio deterioration, including debt-to-equity ratios, cash flow volatility patterns, and industry-specific economic signals. Implementation analysis indicates potential cost reductions of 34% compared to traditional risk assessment methods while maintaining compliance with regulatory standards. Furthermore, the system's modular architecture supports incremental deployment, allowing institutions to adopt machine learning capabilities without extensive infrastructure overhaul.
subject: Articles
  topic: section
subject: credit risk assessment
  topic: keywords
subject: ensemble learning
  topic: keywords
subject: early warning systems
  topic: keywords
subject: small financial institutions
  topic: keywords
creator: Yifei Li
creator: Sida Zhang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-13
publication date: 2025-11-13
starting page: 372
ending page: 383

Research on Mobile Advertising Click-Through Rate Prediction Algorithm Based on Differential Privacy
type: item
description: Mobile advertising represents a key revenue stream in digital marketing, driven primarily by personalized content. Its effectiveness relies heavily on click-through rate (CTR) prediction models based on user behavior. With growing privacy concerns and increasingly stringent data protection regulations, ensuring user privacy in CTR prediction has become an essential requirement. In response, differential-privacy-based approaches have garnered significant attention. In this study, we propose differentially private mechanisms specifically designed for advanced machine learning models. The approach employs adaptive noise-injection strategies to balance prediction accuracy and privacy effectively. It optimizes the allocation of privacy budgets in CTR estimation while maintaining user anonymity. Experimental results demonstrate that the proposed algorithm achieves prediction accuracy comparable to conventional methods while providing strong privacy guarantees. This framework offers practical solutions that enable mobile advertising platforms to comply with privacy regulations without sacrificing advertising performance.
subject: Articles
  topic: section
subject: differential privacy
  topic: keywords
subject: click-through rate prediction
  topic: keywords
subject: mobile advertising
  topic: keywords
subject: privacy-preserving machine learning
  topic: keywords
creator: Xin Lu
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-13
publication date: 2025-11-13
starting page: 362
ending page: 371

Research on Intelligent Firmware Vulnerability Detection and Priority Assessment Method Based on Hybrid Analysis
type: item
description: Binary firmware underpins critical infrastructure but often contains vulnerabilities that conventional detection mechanisms fail to identify. In this work, we develop a hybrid analytical framework that integrates static pattern extraction with runtime behavioral monitoring, achieving detection rates of 93.7% across a corpus of 40 million procedures collected from production firmware. Static pattern recognition leverages control flow graph embeddings, while probabilistic scoring quantifies contextual risk. Cross-architecture evaluation across ARM, MIPS, x86, and PowerPC demonstrates robustness against variations in compilation. Our methodology also uncovers zero-day vulnerabilities, and the computational overhead remains manageable for deployment on resource-constrained platforms, reducing false positive rates by 56.7% compared to existing approaches.
subject: Articles
  topic: section
subject: firmware vulnerability detection
  topic: keywords
subject: hybrid analysis
  topic: keywords
subject: priority assessment
  topic: keywords
subject: embedded security
  topic: keywords
creator: Xiaoyi Long
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-13
publication date: 2025-11-13
starting page: 350
ending page: 361

Multi-Source Data Fusion for Short-Term Demand Forecasting of Seasonal Retail Products: An Empirical Study Using Weather and Social Media Signals
type: item
description: Recent advances in machine learning have enabled retailers to leverage diverse data streams for demand prediction, yet most systems continue to rely primarily on historical sales. In this study, we address the challenge of seasonal demand forecasting by integrating meteorological observations, social media activity, and economic indicators with point-of-sale transactions. We propose a hierarchical ensemble that combines gradient boosting machines with bidirectional LSTMs, where component weights adapt according to product category and forecast horizon. Through mutual information screening, we reduce feature dimensionality from 123 to category-specific subsets averaging 38 features, lowering computational costs by 60% while maintaining predictive accuracy. Our approach requires only standard training of the base models along with a lightweight meta-learner, without necessitating end-to-end joint training. Evaluation on 10.3 million transactions from three U.S. retail chains demonstrates that our method achieves a mean absolute percentage error of 19.6%, compared to 37.5% for seasonal naive baselines. Multi-source fusion thus provides a practical pathway to more accurate retail forecasting, without the complexity associated with end-to-end deep learning systems. Crucially, this approach relies on lightweight feature learning and selection techniques combined with meta-learner weighting, rather than on end-to-end joint representation training.
subject: Articles
  topic: section
subject: seasonal demand forecasting
  topic: keywords
subject: multi-source data fusion
  topic: keywords
subject: retail analytics
  topic: keywords
subject: hierarchical ensemble
  topic: keywords
subject: gradient boosting machines
  topic: keywords
creator: Jialu Wang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-13
publication date: 2025-11-13
starting page: 340
ending page: 349

FTAFO: A Federated Transparent Adaptive Financial Optimizer for Reducing Third-Party Dependencies in Workflow Management
type: item
description: Modern financial institutions face increasing challenges due to opaque third-party AI systems governing critical workflow decisions. After firsthand experience with the limitations of existing solutions during a complex 18-month implementation project, we developed FTAFO (Federated Transparent Adaptive Financial Optimizer), a novel framework that fundamentally rethinks financial workflow optimization by introducing three core innovations: a federated consensus mechanism enabling distributed decision-making without reliance on centralized black-box systems, an adaptive transparency engine providing real-time explanations while maintaining computational efficiency, and a multi-objective optimization algorithm that simultaneously balances performance, interpretability, and regulatory compliance. Extensive testing across five financial institutions demonstrated promising results, with workflow processing times improving by approximately 18-28%, third-party licensing costs reduced by roughly 60-70%, and regulatory audit preparation time decreasing from several weeks to around 2-3 days. Implementation revealed challenges including initial setup complexity and the need for substantial staff retraining. Nevertheless, the framework's open architecture offers a practical alternative to vendor lock-in while meeting stringent regulatory requirements. This work contributes to the growing field of explainable AI in finance, though limitations remain in ultra-high-frequency scenarios and environments with restricted technical infrastructure.
subject: Articles
  topic: section
subject: federated optimization
  topic: keywords
subject: financial workflows
  topic: keywords
subject: transparent AI
  topic: keywords
subject: dependency reduction
  topic: keywords
subject: regulatory compliance
  topic: keywords
creator: Ziyi Wang
creator: Aixin Kang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-13
publication date: 2025-11-13
starting page: 329
ending page: 339

Enhanced Multi-Modal Feature Fusion Algorithm for Early-Stage Cancer Detection: A Comparative Study of Optimization Strategies
type: item
description: This study presents an adaptive multi-modal fusion algorithm for early-stage cancer detection that dynamically integrates imaging, genomic, and clinical data using learned attention mechanisms. Unlike traditional approaches that treat fusion weights as fixed parameters, our method models them as probabilistic distributions, allowing adaptation to variations in data quality and modality availability in clinical environments. The key innovation is a meta-learning framework that predicts optimal fusion strategies based on the characteristics of incoming data. Experimental validation across 12,847 patients from eight medical centers demonstrates an AUROC of 0.947, with 89.3% sensitivity at 95% specificity. The algorithm exhibits particular robustness in managing minority cancer classes through hierarchical attention mechanisms that capture both local and global patterns. Comparative analysis against current state-of-the-art methods shows consistent performance improvements while maintaining computational efficiency suitable for clinical deployment.
subject: Articles
  topic: section
subject: multi-modal fusion
  topic: keywords
subject: cancer detection
  topic: keywords
subject: adaptive attention
  topic: keywords
subject: meta-learning
  topic: keywords
creator: Chuhan Zhang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-13
publication date: 2025-11-13
starting page: 318
ending page: 328

Deep Reinforcement Learning-Driven Efficacy-Toxicity Balance Optimization Strategy for Personalized Drug Combination in Cancer Patients
type: item
description: Precision medicine demands the careful optimization of dose regimens in cancer therapy, particularly when adjusting doses to balance therapeutic effectiveness against adverse toxicities. In this study, we introduce a deep reinforcement learning (DRL) framework that leverages multimodal patient data to optimize personalized drug combination strategies, aiming to maximize efficacy while minimizing toxicity. The DRL agent employs multi-objective reward functions to identify optimal treatment strategies by integrating genomic, clinical, and pharmacokinetic data through an advanced feature engineering pipeline. This approach was evaluated in a cohort of 2,847 cancer patients encompassing a diverse range of tumor types. Experimental results demonstrate that the algorithm improved predicted treatment response by 23.4% compared to conventional methods, while reducing serious adverse events by 18.7%. These findings highlight a significant advancement in computational approaches for personalized therapy optimization, providing clinically interpretable outputs to guide patient-specific treatment decisions.
subject: Articles
  topic: section
subject: deep reinforcement learning
  topic: keywords
subject: drug combination optimization
  topic: keywords
subject: personalized cancer therapy
  topic: keywords
subject: multi-objective optimization
  topic: keywords
creator: Haofeng Ye
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-12
publication date: 2025-11-12
starting page: 307
ending page: 317

Graph Attention-Based Feature Selection for Multi-Omics Drug Target Prediction in Cardiovascular Diseases
type: item
description: Drug target identification in cardiovascular diseases faces computational challenges due to the high dimensionality of multi-omics datasets. Here, we present a graph attention framework that integrates genomic variants, proteomic expression profiles, and metabolomic signatures using hierarchical attention mechanisms applied to molecular interaction networks. In these networks, nodes represent molecular entities and edges capture experimentally validated functional associations, thereby encoding key biological relationships. The attention mechanism assigns adaptive importance weights αᵢⱼ to neighboring nodes, facilitating selective feature propagation while maintaining the integrity of biological signals. Validation across three cardiovascular cohorts-encompassing 12,226 patients with whole-genome sequencing, proteomics, and metabolomics data-achieves 87.3% target identification accuracy alongside a 72.0% reduction in feature dimensionality. Analysis of attention weights highlights differential pathway contributions, with MAPK signaling (0.342), calcium homeostasis (0.298), and PI3K-AKT cascades (0.276) identified as principal therapeutic nodes. The framework successfully recovers 23 FDA-approved cardiovascular drugs and predicts 17 investigational compounds currently in clinical trials. Computational complexity decreases from O(n²d) to O(nkd), where k denotes the selected features (k << n), resulting in a 4.2-fold speedup in execution. Gradient-based attribution methods further provide mechanistic interpretability, linking molecular features to pathway-level biological processes. This approach bridges the computational and biological gap in precision cardiovascular medicine by offering mathematically grounded feature selection with preserved mechanistic transparency.
subject: Articles
  topic: section
subject: multi-omics integration
  topic: keywords
subject: graph attention networks
  topic: keywords
subject: drug target prediction
  topic: keywords
subject: cardiovascular diseases
  topic: keywords
creator: Zejun Cheng
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-12
publication date: 2025-11-12
starting page: 294
ending page: 306

Adaptive Privacy-Preserving Techniques for Multimedia Content Processing in Cloud Environments: A Differential Privacy Approach
type: item
description: We propose a novel adaptive differential privacy framework for multimedia content processing in cloud environments, designed to achieve optimal privacy-utility trade-offs through content-aware noise calibration and dynamic budget allocation. The framework introduces three core technical innovations: (1) a sensitivity-guided privacy budget allocation mechanism that reduces utility loss by 38.7% compared to uniform allocation, (2) a frequency-domain noise injection strategy that preserves perceptual quality while ensuring epsilon-differential privacy, and (3) an optimization algorithm that solves the budget allocation problem in O (n log n) time. Extensive experiments on the COCO, AudioSet, and UCF101 datasets demonstrate that the proposed framework maintains 91.3% task accuracy at epsilon = 1.0 while reducing membership inference attack success rates to 52.8%. Moreover, the system processes up to 312 images per second on commodity hardware, underscoring its practicality for deployment in large-scale production cloud environments.
subject: Articles
  topic: section
subject: differential privacy
  topic: keywords
subject: multimedia processing
  topic: keywords
subject: adaptive noise calibration
  topic: keywords
subject: privacy budget optimization
  topic: keywords
creator: Ye Lei
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-12
publication date: 2025-11-12
starting page: 278
ending page: 293

Efficiency Comparison of Automated Tools versus Traditional Methods in Anti-Money Laundering Compliance Auditing for Banking Institutions
type: item
description: Banking institutions process 8.8 million daily transactions requiring anti-money laundering (AML) compliance verification, creating computational and operational challenges that exceed manual processing capabilities. This study quantifies performance differentials between automated compliance systems and traditional manual methods through empirical analysis of 15 banking institutions over 36 months. We develop a multi-dimensional efficiency framework measuring processing speed, detection accuracy, cost structures, and false positive rates across institutional tiers. Automated systems demonstrate 73% increased processing throughput (12,500 transactions/hour versus 7,200), reduce false positive rates from 27.6% to 15.2%, and achieve 89.3% detection accuracy compared to 67.1% for manual methods. Cost-benefit analysis reveals 52% reduction in per-transaction processing costs after five-year amortization periods, with break-even points occurring at 22 months post-implementation. Machine learning algorithms employing pattern recognition reduce Type I errors by 45% while increasing genuine threat detection by 62%. The framework incorporates real-time transaction monitoring, customer due diligence protocols, and suspicious activity reporting mechanisms. Implementation analysis across three institutional tiers (assets > $200B, $50-200B, < $50B) demonstrates scalability constraints and resource allocation patterns. Hybrid approaches combining automated screening with selective manual review optimize performance across eight evaluation dimensions (speed, precision, recall, F1, false-positive rate, cost / tx, scalability@200% load, p99 latency). These findings establish quantitative benchmarks for compliance technology adoption while identifying implementation barriers and regulatory acceptance factors.
subject: Articles
  topic: section
subject: anti-money laundering
  topic: keywords
subject: automated compliance tools
  topic: keywords
subject: banking auditing
  topic: keywords
subject: artificial intelligence
  topic: keywords
subject: regulatory technology
  topic: keywords
creator: Liya Ge
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-11
publication date: 2025-11-11
starting page: 265
ending page: 277

Data-Driven Analysis of Transportation Route Efficiency and Carbon Emission Correlation in Retail Distribution Networks
type: item
description: Transportation networks coordinate intricate patterns of efficiency and sustainability within retail distribution systems. This study quantitatively examines the relationships between route optimization parameters and carbon emission trajectories through an extensive empirical analysis encompassing 2,847 distinct delivery routes. Statistical evaluations-using Pearson correlation (r = -0.742, p < 0.001) and Spearman rank analysis-reveal strong interdependencies between operational efficiency and environmental impact indicators. Multivariate regression models accounting for 73.8% of emission variance demonstrate that strategic route consolidation enhances operational efficiency by 23.7% and reduces emissions by 18.4% (quasi-experimental estimate: 19.3%; see Section 4.2). Among all variables, load factor optimization exhibits the highest correlation with emission reduction (r = -0.836). The derived performance metrics integrate both operational and environmental dimensions, highlighting that urban networks possess an optimization potential of 21.4%, significantly surpassing rural networks at 12.8%. Notably, operational optimization alone achieves 78.4% of the theoretical emission reduction potential without the necessity of additional technological interventions.
subject: Articles
  topic: section
subject: supply chain sustainability
  topic: keywords
subject: transportation efficiency
  topic: keywords
subject: carbon emission analysis
  topic: keywords
subject: retail logistics
  topic: keywords
creator: Yi Wang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-11
publication date: 2025-11-11
starting page: 253
ending page: 264

AI-Enhanced Cybersecurity for Financial Networks: A Federated Learning Implementation
type: item
description: During a 14-month deployment across four financial institutions, including a tier-1 bank in the Northeast US, we developed a hybrid threat detection system that integrates Transformer models with Graph Neural Networks. The system was implemented using Python 3.8.10 and PyTorch 1.12.1 on NVIDIA RTX 3090 GPUs (24GB VRAM). Our team, despite frequent methodological disagreements, achieved a detection accuracy of 86.7%, which fell short of the anticipated 95% or higher. The federated learning component, initially planned for six months, was extended due to regulatory compliance requirements. This component enables collaborative threat intelligence while preserving data privacy. Under normal operating conditions, the system processes approximately 1.1 million events per second, with throughput decreasing to around 400,000 events per second during periods of market volatility, such as Q4 2023. The architecture reduces false positives to 2.1%. Implementation costs exceeded the original $127,000 NSF grant by roughly 40%, necessitating additional university cost-sharing. Three preliminary approaches were abandoned before the current architecture was finalized. Real-world deployment highlighted hardware bottlenecks that were not evident in simulations, requiring compromises in system design. The system is now operational in production, although stability issues persist during high-frequency trading periods.
subject: Articles
  topic: section
subject: financial cybersecurity
  topic: keywords
subject: federated learning
  topic: keywords
subject: graph neural networks
  topic: keywords
subject: transformers
  topic: keywords
subject: regulatory compliance
  topic: keywords
creator: Jiahui Han
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-11
publication date: 2025-11-11
starting page: 241
ending page: 252

Medical Terminology Definition-Enhanced Retrieval-Augmented Generation for Hallucination Mitigation in Medical Question Answering
type: item
description: The rapid emergence of large language models (LLMs) in healthcare applications presents critical challenges related to factual accuracy and hallucination control. This paper proposes an alternative approach that integrates enhanced medical terminology definitions with retrieval-augmented generation (RAG) techniques to mitigate hallucinations in medical question-answering systems. The primary technical contributions include: (1) a Medical-Adaptive Confidence Calibration (MACC) algorithm that departs from traditional RAG methods by dynamically adjusting thresholds based on clinical risk; (2) a multi-source medical knowledge fusion framework that incorporates hierarchical relationships from SNOMED-CT, UMLS, and ICD-10; and (3) a comprehensive robustness validation procedure featuring real-time monitoring. The proposed approach achieves substantial accuracy improvements, reducing hallucinations by 23.7% (p < 0.001, 95% CI: 19.4%, 28.0%) compared with baseline systems. Experimental evaluations on medical consultation datasets demonstrate superior precision and reliability in clinical information delivery, yielding an 18.4% increase in precision and a 15.2% enhancement in recall. The framework effectively addresses major limitations of existing automated medical consultation systems while maintaining computational efficiency and scalability for practical deployment.
subject: Articles
  topic: section
subject: medical question answering
  topic: keywords
subject: hallucination mitigation
  topic: keywords
subject: retrieval-augmented generation
  topic: keywords
subject: medical terminology
  topic: keywords
creator: Haoyang Guan
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-10
publication date: 2025-11-10
starting page: 222
ending page: 240

Cultural-Intelligent Dynamic Medical Animation Generation for Cross-Lingual Telemedicine Communication Enhancement
type: item
description: Cross-lingual communication in telemedicine presents significant challenges that impede effective healthcare delivery across diverse cultural contexts. Traditional medical visualization approaches fail to address cultural nuances and language barriers that affect patient comprehension of complex medical information. This research introduces a novel cultural-intelligent dynamic medical animation generation framework designed to enhance cross-lingual telemedicine communication through adaptive visualization technologies. The proposed system integrates multi-modal medical data processing with cultural context recognition algorithms to generate culturally sensitive medical animations in real-time. Cultural adaptation mechanisms analyze patient demographics, linguistic preferences, and medical terminology complexity to dynamically adjust visual representation strategies. The framework employs semantic medical concept translation engines coupled with patient comprehension assessment modules to optimize communication effectiveness. Experimental validation demonstrates significant improvements in patient understanding rates across different cultural backgrounds, with cross-cultural user studies showing 73.2% enhancement in medical concept comprehension compared to conventional static visualization methods. Performance analysis reveals computational efficiency suitable for real-time telemedicine applications, with average animation generation latency of 2.8 seconds and scalability supporting concurrent multi-user sessions. The system addresses critical gaps in culturally aware healthcare technology, particularly benefiting underserved populations with limited medical literacy and non-native language speakers seeking remote medical consultations.
subject: Articles
  topic: section
subject: medical visualization
  topic: keywords
subject: cross-lingual communication
  topic: keywords
subject: cultural adaptation
  topic: keywords
subject: telemedicine animation
  topic: keywords
creator: Zi Wang
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-10
publication date: 2025-11-10
starting page: 209
ending page: 221

AI-driven Sustainable Urban Intelligence: Integrating Smart Technologies for Efficient, Resilient, and Inclusive City Management
type: item
description: Artificial intelligence (AI) is increasingly shaping the evolution of urban ecosystems, yet current implementations often optimize isolated objectives—such as efficiency or automation—without integrating environmental and social dimensions. This study proposes a three-layer framework for sustainable urban intelligence, encompassing cognitive, behavioral, and environmental layers to harmonize personalization, mobility optimization, and carbon management. The cognitive layer leverages large language models and knowledge graphs for sustainability-oriented recommendation; the behavioral layer employs reinforcement learning and graph neural networks for adaptive mobility optimization; and the environmental layer integrates AI-enabled carbon forecasting and energy management. Through cross-layer data flow and dynamic feedback loops, the framework establishes an adaptive AI ecosystem that connects human decision-making, technological performance, and ecological feedback. The proposed model advances the conceptual transition from “smart cities” to sustainably intelligent cities, providing a blueprint for future urban AI systems that optimize not only for humans, but with humans—aligning personal actions with collective sustainability goals.
subject: Articles
  topic: section
subject: artificial intelligence
  topic: keywords
subject: sustainable urban intelligence
  topic: keywords
subject: multi-agent systems
  topic: keywords
subject: carbon management
  topic: keywords
subject: urban sustainability
  topic: keywords
creator: Haoran Zhang
creator: Yuting Lin
creator: Grace Nguyen
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-07
publication date: 2025-11-07
starting page: 201
ending page: 208

Machine Learning and Cloud-Enhanced Real-Time Distributed Systems for Intelligent Urban Services
type: item
description: Real-time distributed systems have become fundamental to modern digital infrastructure, yet current centralized or semi-distributed frameworks still face major limitations in predictive accuracy, response latency, and resource utilization. In critical domains such as public safety and telecommunication network management, these shortcomings result in delayed decision-making, inefficient resource allocation, and vulnerability to network disruptions. To address these challenges, this paper proposes an intelligent real-time distributed architecture integrating machine learning (ML) and cloud computing (CC). By combining ML-driven predictive analytics with cloud-based elastic resource orchestration, the proposed framework enhances adaptive scheduling, dynamic fault tolerance, and real-time decision-making across heterogeneous nodes. This hybrid approach enables systems to anticipate network anomalies, optimize load distribution, and allocate resources in a risk-informed, latency-aware manner. Case studies in public safety emergency communication systems and telecommunication network optimization demonstrate how multi-source data integration, AI-assisted analytics, and cloud-edge-end collaboration can improve operational resilience, accelerate response times, and strengthen system reliability. Results indicate that the integration of ML and CC not only overcomes traditional bottlenecks but also establishes a scalable foundation for intelligent, self-adaptive distributed infrastructures. This study contributes to the advancement of resilient, data-driven urban systems and aligns with national strategic goals for digital infrastructure security, real-time disaster response, and intelligent network governance.
subject: Articles
  topic: section
subject: real-time distributed systems
  topic: keywords
subject: machine learning
  topic: keywords
subject: cloud computing
  topic: keywords
subject: public safety
  topic: keywords
subject: telecommunication network optimization
  topic: keywords
subject: adaptive scheduling
  topic: keywords
subject: edge-cloud collaboration
  topic: keywords
subject: intelligent infrastructure
  topic: keywords
creator: Guoli Ying
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-11-05
publication date: 2025-11-05
starting page: 189
ending page: 200

Fabrication of Copper(II) Coordination Complexes Modulated by Flexible Dicarboxylate Ligands with Notable Urease Inhibitory Performance
type: item
description: Copper(II) complexes have attracted increasing attention as potential urease inhibitors owing to their unique coordination versatility, structural diversity, and intrinsic biocompatibility. Urease, a nickel-containing metalloenzyme responsible for the hydrolysis of urea, plays a key role in various pathological processes, making its inhibition a promising therapeutic strategy. In this work, a series of copper(II) complexes were rationally constructed using flexible dicarboxylate ligands as structural modulators to fine-tune molecular geometry and supramolecular organization. The synthesized complexes were comprehensively characterized by infrared and UV–visible spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction, which revealed the diverse coordination environments of the copper centers, the variable chelation behaviors of the ligands, and the intricate network of hydrogen bonding and π–π stacking interactions within the crystal lattices. Biological assays demonstrated that the obtained complexes exhibit pronounced and tunable urease inhibitory activities, with several compounds achieving inhibition efficiencies comparable to or exceeding those of known reference inhibitors. Correlation of structural parameters with bioactivity revealed that the degree of ligand flexibility, denticity, and spatial arrangement around the copper center collectively govern enzyme binding affinity and inhibition strength. These findings underscore the importance of molecular design in modulating metal–enzyme interactions and provide new insights into the structure–activity relationships governing copper-based inhibitors. Overall, this study establishes a strategic framework for the development of efficient, adaptable copper(II)-based urease inhibitors, offering both theoretical foundations and experimental references for future exploration in metalloenzyme inhibition and related biomedical applications.
subject: Articles
  topic: section
subject: Copper(II) complexes
  topic: keywords
subject: flexible dicarboxylate ligands
  topic: keywords
subject: coordination chemistry
  topic: keywords
subject: urease inhibition
  topic: keywords
subject: structure–activity relationship
  topic: keywords
subject: bioinorganic chemistry
  topic: keywords
creator: Marie-Claire Dupont
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-28
publication date: 2025-10-28
starting page: 183
ending page: 188

Efficiency and Productivity Enhancement in Modern Professional Practice: Strategies, Challenges, and Best Practices
type: item
description: Efficiency and productivity enhancement represent critical imperatives for organizations across diverse professional sectors seeking competitive advantage and sustainable performance in increasingly complex operational environments. This paper examines contemporary approaches to productivity improvement through comprehensive analysis of determinants, management practices, technological integration, and human resource strategies that collectively influence organizational effectiveness. The research explores how modern practices in software development, construction management, architectural design, and business operations leverage digital transformation, systematic management methodologies, and performance-oriented human resource systems to achieve superior productivity outcomes. Through examination of empirical evidence and theoretical frameworks, this study identifies key factors driving productivity enhancement including management quality, technological adoption, workforce development, and organizational systems that align individual efforts with strategic objectives. Findings reveal that sustainable productivity improvement requires integrated approaches combining technological capabilities with human resource excellence, systematic management practices, and organizational cultures supporting continuous improvement. The analysis demonstrates that productivity enhancement transcends simple efficiency gains to encompass comprehensive organizational transformation that builds competitive capabilities while maintaining workforce engagement and operational sustainability. This synthesis provides actionable insights for practitioners seeking evidence-based approaches to productivity improvement applicable across diverse professional contexts.
subject: Articles
  topic: section
subject: productivity enhancement
  topic: keywords
subject: organizational efficiency
  topic: keywords
subject: management practices
  topic: keywords
subject: digital transformation
  topic: keywords
subject: human resources
  topic: keywords
subject: performance systems
  topic: keywords
creator: Wei Sun
creator: Lan Yang
creator: Ting Xu
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-28
publication date: 2025-10-28
starting page: 170
ending page: 182

Design and Synthesis of Novel Copper-Based Coordination Polymers with Enhanced Urease Inhibition Activity
type: item
description: Urease is a key metalloenzyme involved in biological, agricultural, and environmental processes, and its excessive activity can lead to pathogenic infections, nitrogen loss, and environmental pollution. Developing efficient, stable, and controllable urease inhibitors is therefore of considerable significance. In this study, we report the rational design and theoretical framework for novel two-dimensional copper-based coordination polymers (Cu-CPs) regulated by tridentate auxiliary ligands. The integration of multidentate ligands, optimized copper coordination geometries, and tailored polymer architectures enables spatial and electronic complementarity with urease active sites, enhancing inhibitory efficiency. Computational modeling and crystal structure prediction reveal that multinuclear copper centers and functionalized ligands synergistically improve binding and prolong inhibition. The synthetic strategies, including solution-based synthesis, self-assembly, and stepwise assembly, yield highly crystalline and thermally stable polymers, while adhering to principles of green chemistry. The proposed inhibition mechanisms involve direct coordination with the enzyme, steric hindrance, and multivalent effects. These Cu-CPs demonstrate potential applications in medical treatment of urease-producing pathogens, improved nitrogen fertilizer utilization, and environmental nitrogen management. Future work may explore multifetal synergistic designs, high-throughput computational screening, and biocompatibility optimization to develop efficient, selective, and sustainable urease inhibitors.
subject: Articles
  topic: section
subject: copper-based coordination polymers
  topic: keywords
subject: urease inhibition
  topic: keywords
subject: tridentate ligands
  topic: keywords
subject: multinuclear metal centers
  topic: keywords
creator: Liam Harrison
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-27
publication date: 2025-10-27
starting page: 162
ending page: 169

Coordination Polymer Design for Catalytic Efficiency Enhancement
type: item
description: Coordination polymers and metal-organic frameworks represent a revolutionary class of porous crystalline materials that have transformed heterogeneous catalysis through their unprecedented structural tunability, high surface areas, and designable active sites. This review examines strategic design approaches for enhancing catalytic efficiency in coordination polymer systems through rational manipulation of framework topology, metal center selection, ligand engineering, and pore environment optimization. The discussion encompasses reticular chemistry principles that guide framework construction, structure-property relationships governing catalytic performance, and emerging strategies including dual-metal site incorporation and programmable logic systems. Recent advances in copper-based coordination polymers demonstrate how auxiliary ligand selection and geometric control enable optimization of catalytic activities ranging from organic transformations to electrocatalytic carbon dioxide reduction and enzyme inhibition. Through systematic analysis of synthesis methodologies, structural characterization techniques, and catalytic evaluation protocols, this work illustrates fundamental design principles that connect framework architecture to catalytic efficiency. The integration of computational modeling with experimental validation enables predictive catalyst design and accelerates discovery of high-performance systems for industrial applications including wastewater treatment, fine chemical synthesis, and sustainable energy conversion. Understanding coordination polymer design principles provides essential guidance for developing next-generation catalytic materials with enhanced activities, selectivities, and stabilities that address critical challenges in chemical manufacturing and environmental remediation.
subject: Articles
  topic: section
subject: coordination polymers
  topic: keywords
subject: metal-organic frameworks
  topic: keywords
subject: heterogeneous catalysis
  topic: keywords
subject: reticular chemistry
  topic: keywords
subject: catalyst design
  topic: keywords
subject: catalytic efficiency
  topic: keywords
creator: Hui Zhang
creator: Feng Wang
creator: Lei Chen
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-27
publication date: 2025-10-27
starting page: 150
ending page: 161

Auxiliary Ligand Effects on Metal Coordination Polymer Properties
type: item
description: Coordination polymers have emerged as versatile materials with tunable structural and functional properties that can be systematically modified through rational design strategies. The incorporation of auxiliary ligands alongside primary bridging ligands represents a powerful synthetic approach for controlling the dimensionality, topology, and physicochemical characteristics of these materials. This review examines how auxiliary ligands influence the structural assembly and functional properties of metal coordination polymers, with particular emphasis on multicarboxylate-based systems. The discussion encompasses synthetic methodologies, structural diversity, and property modulation including magnetic behavior, luminescence, catalytic activity, and biological applications. Through analysis of recent developments in mixed-ligand coordination polymer design, this work demonstrates how secondary ligands containing nitrogen-donor atoms, particularly imidazole derivatives, can direct framework formation and enhance material performance. The interplay between metal centers, primary carboxylate ligands, and auxiliary nitrogen-containing ligands creates opportunities for developing coordination polymers with predetermined structures and optimized properties for applications in energy storage, catalysis, sensing, and biomedicine.
subject: Articles
  topic: section
subject: coordination polymers
  topic: keywords
subject: auxiliary ligands
  topic: keywords
subject: multicarboxylate ligands
  topic: keywords
subject: mixed-ligand synthesis
  topic: keywords
subject: metal-organic frameworks
  topic: keywords
subject: structure-property relationships
  topic: keywords
creator: Wei Chen
creator: Robert Miller
creator: Yuki Tanaka
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-26
publication date: 2025-10-26
starting page: 141
ending page: 149

Technology-Driven Efficiency Improvements in Modern Professional Fields
type: item
description: Technology-driven efficiency improvements have fundamentally transformed professional practice across diverse industry sectors, reshaping operational methodologies, service delivery models, and organizational capabilities. This paper examines the mechanisms through which technological innovation enhances professional efficiency, analyzing implementation patterns across construction management, manufacturing systems, financial services, software development, digital commerce, and professional practice domains. The investigation reveals that efficiency gains derive from multiple interconnected factors including information management capabilities, digital infrastructure investments, process automation, data analytics integration, and organizational capability development. Empirical evidence demonstrates that organizations achieving superior efficiency outcomes strategically allocate resources toward digital capital formation, develop complementary organizational capabilities, and systematically integrate technological tools into professional workflows. The analysis identifies critical success factors including leadership commitment, workforce competency development, process redesign initiatives, and stakeholder engagement strategies. Emerging trends indicate accelerating convergence toward cloud-based platforms, artificial intelligence integration, real-time collaboration systems, and data-driven decision-making frameworks. The findings provide actionable insights for organizations seeking to leverage technological capabilities for efficiency enhancement while managing implementation challenges inherent in digital transformation initiatives.
subject: Articles
  topic: section
subject: technology efficiency
  topic: keywords
subject: digital transformation
  topic: keywords
subject: professional practice
  topic: keywords
subject: information systems
  topic: keywords
subject: organizational capability
  topic: keywords
subject: process innovation
  topic: keywords
creator: Kevin Martinez
creator: Lan Wu
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-25
publication date: 2025-10-25
starting page: 128
ending page: 140

Performance Optimization Strategies Across Contemporary Industry Practices
type: item
description: Performance optimization has emerged as a critical imperative across diverse industry sectors as organizations navigate increasingly complex operational environments characterized by digital transformation, heightened competition, and evolving stakeholder expectations. This paper examines contemporary performance optimization strategies implemented across multiple professional domains, including manufacturing systems, digital platforms, project management, risk assessment frameworks, and technology-driven service delivery. Through systematic analysis of measurement frameworks, operational methodologies, and strategic interventions, this research identifies common optimization principles that transcend sector-specific boundaries. The investigation reveals that successful performance enhancement depends upon integrated measurement systems, data-driven decision-making processes, continuous improvement methodologies, and adaptive organizational cultures. Emerging trends indicate convergence toward digitally-enabled performance monitoring, real-time analytics integration, and stakeholder-centric value creation models. The findings demonstrate that organizations achieving superior performance outcomes consistently employ systematic measurement approaches, leverage technological capabilities for operational intelligence, and maintain strategic alignment between performance metrics and organizational objectives. This comprehensive analysis provides actionable insights for practitioners seeking to implement robust performance optimization frameworks within their respective operational contexts while acknowledging sector-specific implementation considerations.
subject: Articles
  topic: section
subject: performance measurement
  topic: keywords
subject: optimization strategies
  topic: keywords
subject: digital transformation
  topic: keywords
subject: operational efficiency
  topic: keywords
subject: data analytics
  topic: keywords
subject: contemporary practices
  topic: keywords
creator: Rachel Thompson
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-25
publication date: 2025-10-25
starting page: 115
ending page: 127

Digital Transformation and Innovation Across Interdisciplinary Professional Sectors
type: item
description: Digital transformation has fundamentally reshaped contemporary professional practices across diverse interdisciplinary sectors, driving unprecedented innovation in operational efficiency, strategic planning, and service delivery. This comprehensive study examines the systematic integration of digital technologies and methodologies across nine distinct professional domains including financial services, performing arts education, e-commerce, software development, manufacturing, digital media, construction management, architectural design, and renewable energy systems. The research analyzes how organizations navigate the complexities of digital adoption while addressing sector-specific challenges and opportunities. Through systematic examination of implementation strategies, performance metrics, and adaptation frameworks, this paper demonstrates that successful digital transformation transcends mere technological adoption, requiring fundamental organizational restructuring, capability development, and cultural evolution. The analysis reveals common patterns in digital innovation pathways despite significant sectoral differences, including the critical importance of data-driven decision making, user-centric design principles, and continuous process optimization. Post-pandemic acceleration of digitalization has further emphasized the necessity for adaptive systems capable of rapid reconfiguration in response to environmental disruptions. The findings establish a comprehensive framework for understanding digital transformation as an ongoing strategic renewal process that enables organizations to build dynamic capabilities essential for sustained competitive advantage.
subject: Articles
  topic: section
subject: digital transformation
  topic: keywords
subject: interdisciplinary innovation
  topic: keywords
subject: professional sectors
  topic: keywords
subject: performance optimization
  topic: keywords
subject: strategic renewal
  topic: keywords
subject: digitalization
  topic: keywords
creator: Emily Rodriguez
creator: Jun Li
creator: Thomas Anderson
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-24
publication date: 2025-10-24
starting page: 102
ending page: 114

Bimetallic Systems for Tandem Catalytic Reaction Pathways
type: item
description: Bimetallic catalytic systems have emerged as powerful platforms for enabling tandem reaction pathways that combine multiple chemical transformations in a single operational sequence. These systems leverage the synergistic interactions between two distinct metal centers to facilitate consecutive or cooperative catalytic steps, offering advantages in terms of process efficiency, selectivity, and sustainability compared to conventional single-metal catalysts or sequential batch processes. This comprehensive review examines the fundamental design principles, mechanistic aspects, and diverse applications of bimetallic systems across various tandem catalytic transformations. Special emphasis is placed on the structural configurations that enable effective dual-site catalysis, including spatially separated metal centers, proximal active sites within coordination frameworks, and artificial metalloenzyme architectures. The review discusses key applications in organic synthesis, electrocatalytic carbon dioxide reduction, water oxidation, ammonia oxidation, and waste valorization processes. Through detailed analysis of catalyst-substrate interactions, electronic coupling effects, and cooperative mechanisms, this work provides insights into how rational design of bimetallic systems can unlock new synthetic routes and enhance catalytic performance for sustainable chemical production.
subject: Articles
  topic: section
subject: bimetallic catalysis
  topic: keywords
subject: tandem reactions
  topic: keywords
subject: synergistic catalysis
  topic: keywords
subject: dual-site mechanisms
  topic: keywords
subject: metal cooperation
  topic: keywords
subject: sustainable synthesis
  topic: keywords
creator: Maria Zhang
creator: James Park
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-23
publication date: 2025-10-23
starting page: 90
ending page: 101

Metal-Organic Framework Stability in Environmental Conditions for Agriculture: Durability and Performance Analysis
type: item
description: Metal-organic frameworks (MOFs) have emerged as promising materials for agricultural applications, offering unique properties such as high surface area, tunable porosity, and selective adsorption capabilities. However, their practical implementation in agricultural environments faces significant challenges related to stability under varying environmental conditions including moisture, temperature fluctuations, and chemical exposure. This comprehensive analysis examines the durability and performance characteristics of MOFs when deployed in agricultural settings, with particular emphasis on water stability, thermal resistance, and chemical compatibility with common agricultural inputs. The study evaluates various modification strategies employed to enhance MOF stability, including ligand selection, metal node optimization, and composite formation approaches. Environmental factors affecting MOF performance are systematically analyzed, including humidity variations, soil pH conditions, and exposure to fertilizers and pesticides. The research demonstrates that while conventional MOFs exhibit limited stability in humid agricultural environments, recent advances in framework design and post-synthetic modifications have significantly improved their durability. Specific attention is given to copper-based coordination polymers and their effectiveness as urease inhibitors in soil applications. The findings indicate that properly engineered MOFs can maintain structural integrity and functional performance under realistic agricultural conditions for extended periods, making them viable candidates for sustainable agricultural technologies including controlled release systems, soil amendment applications, and environmental remediation processes.
subject: Articles
  topic: section
subject: metal-organic frameworks
  topic: keywords
subject: agricultural stability
  topic: keywords
subject: environmental durability
  topic: keywords
subject: water resistance
  topic: keywords
subject: coordination polymers
  topic: keywords
subject: sustainable agriculture
  topic: keywords
creator: Jingyi Sun
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-20
publication date: 2025-10-20
starting page: 80
ending page: 89

Multifunctional Copper-Based Coordination Polymers for Biotechnological Applications: Integration and Performance Evaluation
type: item
description: Copper-based coordination polymers have emerged as versatile multifunctional materials with significant potential in biotechnological applications. This comprehensive review examines the synthesis, structural characteristics, and performance evaluation of copper coordination polymers across various biotechnological domains. The integration of copper centers within polymeric frameworks provides unique properties including antimicrobial activity, catalytic functionality, and therapeutic potential. Recent advances demonstrate that these materials exhibit exceptional performance in drug delivery systems, antimicrobial treatments, enzyme inhibition, and biosensing applications. The multifunctional nature of copper-based coordination polymers stems from their tunable structures, controllable porosity, and diverse coordination environments. This study evaluates the current state of copper coordination polymer research, highlighting key synthesis strategies, characterization methods, and performance metrics. The findings reveal that these materials offer superior biocompatibility, enhanced stability, and targeted functionality compared to conventional approaches. Furthermore, the integration of secondary ligands and structural modifications enables precise control over biological activity and selectivity. The review addresses challenges in scalability, toxicity considerations, and optimization strategies for biotechnological implementation. Current research trends indicate promising applications in personalized medicine, environmental remediation, and advanced therapeutic interventions. The comprehensive analysis demonstrates that copper-based coordination polymers represent a significant advancement in biotechnological materials science, offering unprecedented opportunities for innovative applications.
subject: Articles
  topic: section
subject: copper coordination polymers
  topic: keywords
subject: biotechnology
  topic: keywords
subject: antimicrobial agents
  topic: keywords
subject: enzyme inhibition
  topic: keywords
subject: drug delivery
  topic: keywords
subject: multifunctional materials
  topic: keywords
creator: Ling Zhao
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-18
publication date: 2025-10-18
starting page: 71
ending page: 79

Ligand Architecture Impact on Coordination Polymer Biological Activity: Structure-Function Relationship Studies
type: item
description: Coordination polymers represent a fascinating class of materials where metal centers are connected through organic ligands to form extended network structures with diverse topologies and functionalities. The architectural design of ligands plays a crucial role in determining both the structural characteristics and biological activities of these materials. This comprehensive study investigates the intricate relationship between ligand architecture and the resulting biological properties of co-ordination polymers, focusing on how structural modifications influence antimicrobial, enzyme inhibition, and biocompatibility characteristics. Through systematic analysis of various ligand types including carboxylate, nitrogen-donor, and mixed-ligand systems, we demonstrate that specific structural features such as flexibility, donor atom positioning, and functional group orientation directly correlate with biological efficacy. Our findings reveal that V-shaped auxiliary ligands enhance urease inhibition activity, while biphenyl-dicarboxylate linkers provide optimal frameworks for catalytic applications with biological relevance. The study encompasses detailed structure-activity relationship analyses, examining how ligand conformation versatility affects coordination polymer properties and their subsequent biological applications. Results indicate that careful ligand selection and architectural planning can significantly improve therapeutic potential while maintaining structural integrity. This research provides valuable insights for the rational design of biologically active coordination polymers with enhanced performance characteristics for pharmaceutical and biomedical applications.
subject: Articles
  topic: section
subject: coordination polymers
  topic: keywords
subject: ligand architecture
  topic: keywords
subject: biological activity
  topic: keywords
subject: structure-function relationship
  topic: keywords
subject: enzyme inhibition
  topic: keywords
subject: antimicrobial properties
  topic: keywords
creator: Rong Li
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-16
publication date: 2025-10-16
starting page: 62
ending page: 70

Inorganic Communication Networks through Two-Dimensional Coordination Polymers: Environmental and Biological Applications
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description: The increasing demand for sustainable agricultural practices has intensified research into enzyme inhibition mechanisms that can optimize nitrogen utilization efficiency in soil-plant systems. Urease, a critical enzyme responsible for urea hydrolysis in soils, plays a pivotal role in nitrogen cycling but often leads to significant nitrogen losses through ammonia volatilization when not properly regulated. This study investigates the application of coordination polymers as innovative urease inhibitors in soil-plant systems, focusing on their mechanisms of action, environmental stability, and agricultural implications. Coordination polymers, characterized by their unique structural properties and tunable chemical compositions, offer promising solutions for controlled enzyme inhibition while maintaining soil health and supporting plant growth. The research examines various copper-based coordination polymers and their effectiveness in prolonging urease inhibition compared to conventional chemical stabilizers. Results demonstrate that coordination polymers exhibit superior performance in maintaining enzyme inhibition over extended periods, with minimal adverse effects on beneficial soil microorganisms and plant development. The study also evaluates the impact of these inhibitors on soil carbon, nitrogen, and phosphorus dynamics, revealing enhanced nutrient retention and improved fertilizer use efficiency. Furthermore, the investigation explores the relationship between coordination polymer structure and inhibition selectivity, providing insights into the design of next-generation agricultural amendments. These findings contribute to the development of environmentally sustainable approaches to nitrogen management in agricultural systems, offering potential solutions to reduce greenhouse gas emissions while maintaining crop productivity.
subject: Articles
  topic: section
subject: coordination polymers
  topic: keywords
subject: inorganic communication
  topic: keywords
subject: enzyme inhibition
  topic: keywords
subject: environmental monitoring
  topic: keywords
subject: urease activity
  topic: keywords
subject: metal-organic frameworks
  topic: keywords
creator: Xinxin Liu
rights: Copyright (c) 2025 Journal of Science, Innovation & Social Impact
date: 2025-10-16
publication date: 2025-10-16
starting page: 53
ending page: 61